1. CHLORZOXAZONE is a centrally acting muscle relaxant which has been linked with hepatotoxicity, a rare but serious adverse drug reaction. Other adverse reactions that may be associated with the use of Chlorzoxazone include; gastrointestinal bleeding, drowsiness, dizziness, light headedness and malaise. Studies have also shown that there is no evidence of the superiority of the effectiveness of one muscle relaxant from another; however its combination with analgesics tends to produce superior pain killing effects than the single formulated muscle relaxant.

Currently, two brands of Chlorzoxazone are licensed for distribution in Nigeria by NAFDAC. One of the registered brands is a combination product, while the other brand is a mono-component product of Chlorzoxazone.

In view of the safety concerns on the use of Chlorzoxazone, healthcare providers are advised to prescribe and dispense this drug rationally. NAFDAC also wishes to advise healthcare providers to actively monitor the use of Chlorzoxazone in their patients with regards to its potential to precipitate hepatotoxicity.



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